Purity Expressions Color Shading in Expressions Panel
The Expressions Panel uses color shading—green shades for acceptable purity levels in PrepLC methods, purple shades indicating risk of impurities, red for discarded products, blue for confirmed isomers, and orange for expression errors—with purity calculated from all UV signals.
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Analytical Studio for Affinity Selection-Mass Spectrometry (AS-MS) Overview
Virscidian’s Analytical Studio is a vendor-neutral, customizable software solution that automates and streamlines Affinity Selection-Mass Spectrometry (AS-MS) data analysis by importing compound libraries from various sources, integrating multi-vendor data, and providing flexible screen layouts to enhance productivity, data integrity, and efficient review of complex screening results across multiple injections.
Reducing False Positives from Isotopic Misidentification in AS-MS
Enabling automated X–1 and X–2 isotopic misidentification filters in affinity selection-mass spectrometry (AS-MS) reduces false positive compound hits by 5% by preventing misassignment of isotopic peaks (e.g., M+1 or M+2) as distinct compounds, thereby improving hit list accuracy.
HDX-MS Analysis of SARS-CoV-2 Spike Ectodomain
This study used hydrogen/deuterium exchange mass spectrometry (HDX-MS) to analyze the conformational dynamics of the SARS-CoV-2 spike ectodomain, demonstrating that including deuterated glycopeptides from its 22 N-glycosylation sites increased sequence coverage from 76% to 84%, thereby enhancing the localization of structural rearrangements and overcoming previous coverage gaps caused by glycosylation.
Managing Isomers in AS-MS: The Hidden Challenge in Library Design
Isomers in affinity selection-mass spectrometry (AS-MS) pose significant challenges by sharing identical molecular masses that cause false positives and ambiguous hits, as demonstrated in a 250,000-compound library with only 66,000 unique molecular formulae leading to multiple isomer duplications per well, but these issues can be mitigated through careful library design, plating strategies, and advanced analytical tools like Analytical Studio’s enhanced cross-hit filter that individually analyzes isotope peaks to reduce isomer-related misidentifications.
Luma Antibody & Protein Engineering Solution for End-to-End Antibody Discovery
Dotmatics has launched the Luma Antibody & Protein Engineering Solution, the first in its Luma Multimodal R&D Solutions series, which integrates the Dotmatics Luma Scientific Intelligence Platform with key tools like Geneious, GraphPad Prism, and others to streamline and unify antibody discovery and development—particularly for monoclonal and multispecific antibodies—while supporting a broad range of therapeutic modalities including CAR-T, siRNA, ADCs, CRISPR, and vaccines within a collaborative, multimodal research environment.
From Genomics to Proteomics: How Integrated Multi-Omic Data Is Driving Precision Medicine Forward
The article discusses how the integration of diverse multi-omic data—including genomics, proteomics, imaging, diagnostics, and electronic health records—combined with interdisciplinary collaboration among researchers, clinicians, technologists, and policymakers, is driving the advancement of precision medicine by enabling more accurate disease understanding, personalized treatment, and improved patient outcomes.