End-to-End Flow Cytometry Workflow Optimization with Luma + OMIQ
Dotmatics addresses the challenges of manual data handling in flow cytometry workflows by integrating technologies like Luma and OMIQ to automate dataflows, minimize errors, and provide a seamless, end-to-end solution that unites instrument data, advanced analysis tools, and FAIR-compliant data management for optimized panel design, experiment planning, data acquisition, analysis, visualization, and contextualization.
Introduction: Modern Tools, Manual Data Handling
Despite advances in flow cytometry software and instrumentation, researchers still face significant challenges moving data across the research workflow. To progress from initial idea to actionable insights, researchers must transition through several steps, including:
- Designing and optimizing panels (including for high-dimensional assays)
- Planning and requesting experiments using an ELN/LIMS
- Acquiring raw results data from instruments
- Performing classical and modern flow data analysis with specialty software
- Storing, parsing, and converting results
- Modeling and visualizing flow data
- Integrating and contextualizing data with ancillary sources, such as clinical data
Navigating these stages often requires manual data handling across various software, instruments, external systems, siloed data sources, file shares, and spreadsheets. This process wastes time, increases the risk of errors, and makes it difficult to uncover insights. While solutions like JSON conversion can help standardize instrument data, they do not fully address the challenges of advanced analyses and deeper contextualization later in the workflow. Dotmatics aims to change this paradigm.
Optimizing Workflows by Facilitating Dataflows
Addressing the disconnect between complex workflows and manual dataflows allows flow cytometry teams to optimize their analysis. Dotmatics provides core technology that unites instruments, data, and specialty software needed for modern flow cytometry analysis. The Dotmatics flow cytometry analysis solution minimizes manual data handling, automates repetitive steps, and delivers clean, organized, well-tagged, FAIR-compliant data alongside advanced analysis tools.
Luma and OMIQ Integration: A Synergistic Solution for End-to-End Optimization
Dotmatics integrates essential technologies for modern flow cytometry analysis, optimizing entire workflows. Key integrated technologies include:
- The AI-powered Luma data management platform for instrument integration, data acquisition and processing, and workflow/dataflow automation
- The OMIQ cloud-based cytometry analysis platform, offering classical manual analysis, 30+ advanced algorithms, autogating functionality, and customizable, shareable, automatable, and auditable analytical workflows
These products form the core of the integrated Dotmatics flow cytometry solution, enabling:
- Integration of data management and analysis tools (classical, advanced, statistical, sequence) on a bi-directional platform built on Databricks
- Automated instrument data uploads with intelligent parsing
- Customizable metadata tagging of FCS files
- Creation of a searchable, scalable repository of interoperable FAIR-compliant data
- Contextualization of cytometry results with ancillary data (experiment, patient, clinical, and genomics data)
- Seamless dataflow across an auditable end-to-end research workflow
With these capabilities, researchers can more quickly transform raw cytometry results into informed insights that drive decision making.
On-Demand Webinar: Rethinking Flow Cytometry - Eliminating Manual Data Handling with the Luma and OMIQ Integration
To learn more about this approach to optimizing flow cytometry analysis, an on-demand webinar is available: "Rethinking Flow Cytometry - Eliminating Manual Data Handling with the Luma and OMIQ Integration."
Topics explored include:
- Manual data handling pitfalls that slow down and compromise cytometry analysis
- Automated analysis benefits, including improved efficiency and reduced human error
- Instrument and software options to accelerate data transfers and decision making
- Dotmatics’ end-to-end integrated solution that streamlines the cytometry analysis process by enabling automatic instrument data uploads, intelligent metadata tagging, autogating, and in-depth cytometry and statistical analyses
Real-time demos illustrate how the integrated Dotmatics flow cytometry solution helps optimize and automate workflow steps such as:
- Gathering results data for analysis
- Supplementing with experimental metadata (compound, sample, concentration, and target data for dose-response analysis)
- Running advanced cytometry analysis workflows with OMIQ (e.g., autogating)
- Exporting results for further exploration (e.g., Prism statistical analysis)
Presenters Include:
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Phil Mounteny (Regional VP, Science & Technology, Dotmatics)
Phil holds a PhD in Polymer Chemistry and has extensive experience at the intersection of science and technology. At Dotmatics, he has led application scientist teams and now serves as Regional VP of Science and Technology, working closely with customers to deliver solutions that meet market needs. -
Julia Prier (Senior Product Manager, OMIQ)
Julia has a PhD from the University of Melbourne and conducted postdoctoral research in Singapore. Her work combines flow cytometry, sequencing, and machine learning to understand cells critical for defense against cancer and viruses. She has over 10 years of laboratory experience in immunology, virology, molecular biology, cell biology, and bioinformatics.
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