Luma Antibody & Protein Engineering Solution for End-to-End Antibody Discovery

The first in a series of Dotmatics Luma Multimodal R&D Solutions

Geneious has been seamlessly composed into Luma showcasing cross-therapeutic capabilities within a unified platform

Dotmatics announced the launch of Dotmatics Luma™ Multimodal R&D Solutions to support the discovery and development of therapeutics across multiple modalities of biopharmaceutical science. The first solution is the Luma Antibody & Protein Engineering solution, designed to streamline the antibody discovery and development process, with a focus on monoclonal and multispecific antibodies.

The Luma Antibody & Protein Engineering Solution and future multimodal solutions combine the Dotmatics Luma Scientific Intelligence Platform and key Dotmatics scientific tools, composed within Luma. These solutions offer researchers a multimodal approach to therapeutic discovery, supporting CAR-T cell discovery, siRNA, antibody-drug conjugates (ADCs), CRISPR therapeutics, and vaccine discovery.

Michael Swartz, Chief Strategy Officer at Dotmatics, stated that customers are increasingly seeking tools that support multiple modalities of therapeutic discovery. Dotmatics provides a scientific intelligence platform built to support this need, enabling scientists to research and test across different domains of science.

These multimodal Luma solutions leverage capabilities from Dotmatics' scientific software products, including Geneious®, GraphPad® Prism, OMIQ®, Protein Metrics Byos®, and FCS Express®, all composed to work together within Luma. This integration allows researchers to use familiar tools while eliminating data and process silos, fostering a more cohesive and collaborative environment.

Introducing Geneious Luma

Geneious Luma is the first scientific product composed within Luma. It provides researchers with tools to analyze and visualize DNA, RNA, and protein sequences from Geneious Prime, as well as antibody discovery and screening capabilities from Geneious Biologics.

Geneious Luma and future Dotmatics scientific products will come pre-configured to work seamlessly within Luma, allowing IT and scientists to compose their own sequence of low-code actions. This eliminates the need for lengthy customization or complex integrations, enabling immediate benefit from the end-to-end solution. These products will be available to license with the Luma platform and include out-of-the-box Luma applications to fill critical workflow gaps, such as:

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  Multimodal Registration: Versioned, entity-specific, and extensible registration models driven by linked ontologies for scientific depth and precision. Registration happens automatically and asynchronously, tracking and storing experimental and product-related information throughout R&D. If a synthesized molecule does not match the design, Luma can modify the linked registered entity without losing lineage or context.

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  Unified Results: Project data—including molecule designs, characterization data, assay data, endpoint data, and registered materials—can be unified into normalized data structures and customizable dashboards. This enables quick decision-making about which antibodies to advance, eliminating hours of manual data wrangling.

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  Customer Apps: Customers can extend Dotmatics Luma apps or create their own low-code apps to contextualize, flow, and correlate data from disparate sources. These apps feature scientifically smart dashboards and visualizations, follow industry standard SDLC processes, and adhere to FAIR data principles. Data integration options include REST, GraphQL, and JDBC.

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  Artificial Intelligence: Luma includes generative and predictive ML capabilities for dry lab and wet lab tasks. Assistive GenAI accelerates data introspection, summarization, and visualization. Domain-specific AI supports protein prediction, flow cytometry autogating, and other scientific models. Composite AI enables the use of multiple models or datasets for higher order model training, selection, and execution.

The Luma Antibody & Protein Engineering Solution

By composing Geneious Luma and other scientific products within Luma, Dotmatics offers a new solution for addressing the complexities of antibody and protein engineering.

Kalim Saliba, Chief Product Officer at Dotmatics, noted that the Luma Antibody & Protein Engineering solution addresses long-standing gaps in the antibody discovery workflow by providing an end-to-end process that integrates many of scientists’ favorite tools directly into Luma. Researchers can streamline workflows from planning and in-silico design to wet lab production, validation, and data analysis within a unified AI-native platform.

The following products, composed within Luma, support the Luma Antibody & Protein Engineering solution:

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  Geneious Luma: Enables researchers to use advanced bioinformatics, molecular biology, and antibody discovery capabilities of Geneious Prime® and Geneious Biologics® to annotate and filter sequences and design constructs. Researchers can execute cloning, expression, and purification tasks using Luma’s Adaptive Workflow capabilities.

  Customers will also have access to BioGlyph®, enabling the design and generation of multispecific antibody formats and execution of predictive machine learning models to score potential multispecific antibodies, allowing exploration of all combinations and selection of the most promising formats.

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  Prism Luma: Leverages GraphPad Prism for antibody assay development and screening. Includes native normalization and pre-processing of results prior to analysis in Prism, and contextual linking between assay results, registered materials, and experimental context.

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  Byos & Byosphere Luma: Uses Protein Metrics Byos for streamlining protein characterization, feeding characterizations back into predictive machine learning models to drive synthesis. Byosphere enables combining biotherapeutic mass spec data, analysis, and reporting, and curating, interrogating, and sharing analytical lab information.

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  Luma Lab Connect: Automates data ingestion from lab instruments, including flow cytometry, liquid chromatography, mass spectrometry, and other sources. Lab Connect auto-associates instrument results with workflow steps, materials, and endpoint data, mitigating manual pain points of SDMS and LIMS systems.

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  Flow Luma: Uses OMIQ for evaluating molecular properties of antibody candidates, the cells that produce them, and phenotyping their therapeutic outcomes.

Expanding Beyond Biopharma

Dotmatics Luma is designed to extend beyond biopharma and drug discovery into broader scientific domains such as material science, chemistry, industrial biotech, and agritech. Every solution built on the Luma platform ensures a unified user experience and seamless work and data flows, helping organizations achieve scientific breakthroughs faster and with greater accuracy. Dotmatics aims to support researchers across multiple industries, fostering innovation and collaboration.