Stop Compromising on Speed or Accuracy in Antibody Discovery

The choice between speed and accuracy is one that many antibody discovery teams have been forced to make as the complexity of their workflows grows beyond the capabilities of their disconnected research tools.

Instead of compromising on one and focusing on the force that is deemed more important, a trio of experts show how to enhance both speed and accuracy for antibody discovery research with a collaborative antibody selection workflow.

Three Key Steps in an Antibody Discovery Workflow

The experts discuss three critical steps for achieving a collaborative approach:

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  Step 1 - Target Identification:

  • ​Use a forms-based query tool to search registered antibodies for targets of interest. Search criteria may be broad-ranging, such as all antibodies in an overarching project, or more granular, such as antibodies that had titer results in a specific range.
  • ​Users can easily request additional analyses from their screening group.
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  Step 2 - Target Screening:

  • ​Customize screening parameters
  • ​Manage plate setup
  • ​Define controls
  • ​Perform analyses (such as IC50)
  • ​Knock out wells
  • ​Visualize results in different ways (plates, samples, layers, overlays, etc.)
  • ​Upload associated files
  • ​Set-up countersigning requirements

  The presenters demonstrate efficiency gains when screening teams work within the same system as project scientists. They show how to quickly download requested batches, add them to a new experiment, and automatically tie results back to samples.

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  Step 3 - Candidate Selection:

  • ​Narrow down candidates by associating bioassay data (e.g., IC50 values) with annotated sequence data
  • ​Filter sequences based on assay data
  • ​Align whole sequences, or regions of interest, to better understand how they relate to each other

Enhance Both the Speed and Accuracy of Your Research

To help teams overcome the speed and accuracy conundrum, Dotmatics launched the Dotmatics Biology Solution for Antibody Discovery—the market’s first true end-to-end antibody workflow solution. Delivered on Dotmatics’ data platform, the solution unites time-tested antibody discovery tools, including Geneious Biologics, Geneious Prime, SnapGene, and GraphPad Prism, to let researchers achieve both speed and accuracy as they make, test, and select therapeutic antibody candidates.

How does it do this? Here are a few of the ways:

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  Efficient data handling:

  • ​Data are easily collected, standardized, and progressed throughout the discovery workflow, without time-consuming or error-prone data wrangling. Hours of preparing, mapping, and moving data are now replaced with just a few button clicks.
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  Streamlined workflows:

  • ​Researchers can create cross-team workflows that leverage trusted tools for antibody sequencing, bioinformatics, assay screening, experiment planning, and more. Customizable, pre-built templates help teams hit the ground running.
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  Better collaboration:

  • ​Teams can securely make requests, manage workload, and share insights to drive better decisions and keep projects moving.

Researchers are encouraged to get a demonstration of the Antibody Discovery workflow to see how they can leverage a solution that accelerates antibody research while also improving the accuracy of data and findings.